Isabel is a bereavement social worker at Mission Hospice, where she counsels children and adults, supervises interns, and facilitates expressive writing groups and other support groups for those who are grieving. She also specializes in complicated grief treatment and suicide loss. She has lived with cystic fibrosis (CF) for 49 years and received a double lung transplant seventeen years ago. Isabel has been an active leader for various CF and organ transplant organizations for three decades. Isabel and her late twin, Ana, published the memoir, "The Power of Two: A Twin Triumph Over Cystic Fibrosis," and served as international patient advocates in her mother's country, Japan, which led to the creation of a documentary film of the same title. Isabel has lectured around the country on topics such as mental health, resiliency, grief and loss, psychosocial aspects of illness, end-of-life issues and organ donation, including a TEDx Stanford talk in 2014.